It is defined as of dyspnoea, cough, chest tightness and wheezing, that vary over time and in intensity, together with variable expiratory airflow limitation. that result with narrowing of airway
Asthma is usually associated with bronchial hyper-reactivity
classification
early onset
late onset
etiopathogenesis
1. Bronchialhyper-responsiveness.
2. Inflammatory reaction in bronchial wall
cells involves in release of mediaters
Mast cells
• Macrophages
• Eosinophils
• Lymphocytes
mediaters are
Histamine
• Prostaglandins (PGD2, PGF2a and PGE2)
• Thromboxane
Leucotrienes
• Platelet activating factor
• Bradykinin
• TNF-cx, IL-4, IL-5
Investigations------
Chest radiography:
Pulmonary function tests
abg
Skin hypersensitivity tests
Elevated serum IgE levels.
managment------
3-adrenoreceptoragonists.
Methylxanthines.
Corticosteroids.
Chromones.
Anticholinergics.
Leucotriene inhibitors.
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